All Categories

  • All Categories
  • Allergy
  • Antibiotics
  • Antiseptics
  • Cardiovascular
  • Contraception
  • Dentes and mouth
  • Dermatology
  • Endocrinology
  • Eyes and vision
  • Food supplements
  • Genito-urinary system
  • Hemorrhoids
  • Herbal tea
  • Herbs
  • Homoeopathy
  • Hormonal
  • Immune system
  • Joints and bones
  • Medical accessories
  • Medical cosmetology
  • Men's Health
  • Midwifery, gynaecology
  • Miscellaneous
  • Natural oils and tincture
  • Neurology
  • Oncology
  • Otolaryngology
  • Pain relief
  • Poisoning
  • Respiratory system
  • Stomach, bowels, livers
  • Vitamins

Aprovel tabs 150mg #28

  • $31.94
  • 3 or more $31.50
  • Availability:In Stock

User manual for AprovelReed more and buy Aprovel hereCompositionIn 1 tablet of irbesartan 150 or 300 mg.Silicon dioxide, lactose monohydrate, magnesium stearate, MCC, croscarmellose sodium, hypromellose - as excipients.Release for..

Tags: tabs

User manual for Aprovel

Reed more and buy Aprovel here


In 1 tablet of irbesartan 150 or 300 mg.
Silicon dioxide, lactose monohydrate, magnesium stearate, MCC, croscarmellose sodium, hypromellose - as excipients.

Release form

Tablets in a film cover.

pharmachologic effect


Pharmacodynamics and pharmacokinetics


Angiotensin II receptor antagonist. It causes an increase in renin and angiotensin II in the blood and a decrease in the concentration of aldosterone. The concentration of potassium in the blood does not change.
Dose-dependently reduces blood pressure, but when used above 900 mg / day, the increase in the hypotensive effect is insignificant. A decrease in blood pressure is observed after 3–6 hours, the effect is maintained for 24 hours.
Hypotensive effect increases 1-2 weeks., And the maximum is detected in 1-1.5 months. Efficiency does not depend on gender. The drug does not affect the level of uric acid in the blood. Cancellation syndrome is not marked.
Irbesartan does not affect the kidney function in patients with diabetic nephropathy, glomerulonephritis, therefore, it is the drug of choice in these patients.


Well absorbed, bioavailability of 60-80%. The maximum concentration is determined in the blood after 1.5-2 hours, the equilibrium concentration after 3 days. Binds to proteins by 96%.
Metabolized by the cytochrome P450 CYP2C9 liver system. Excreted by the liver and kidneys. T1 / 2 is 11-14 hours. Patients with dysfunction of these organs, as well as the elderly, do not adjust the dose.

Indications for use

Aprovel is used for:
    primary hypertension;
    secondary hypertension;
    kidney damage in diabetes and other diseases.
It is prescribed with caution in hyponatremia, aortic valve stenosis, renal artery stenosis, coronary heart disease, severe hepatic and renal failure.


Aprovel is not appointed when:
    hereditary intolerance to galactose;
    under the age of 18.

Side effects

Aprovel can cause:
    dizziness, orthostatic hypotension;
    cough, chest pain;
    nausea, vomiting, diarrhea, heartburn;
    sexual dysfunction;
    increased CK, hyperkalemia;
    pain in the bones and muscles;
    rash, urticaria, angioedema.

Instructions for use Aprovel (method and dosage)

The pill is taken orally without chewing. Treatment begins with 150 mg 1 time per day, this dose provides control of blood pressure for 24 hours. With ineffectiveness, the dose rises to 300 mg.
In diabetes mellitus type II with arterial hypertension, 150 mg / day is administered first, with an increase of up to 300 mg, since this dose is more preferable in the treatment of nephropathy. Persons over 75 years old and patients on hemodialysis receive the drug in an initial dose of 75 mg. The appointment of a diuretic enhances the effect of the drug.
The drug Co Aprovel is a combination of Irbesartan + hydrochlorothiazide at dosages of 150 mg / 12.5 mg and 300 mg / 12.5 mg.
Instructions for use Aprovel contains information that a violation of the kidney and liver in patients does not require dose adjustment.


Reception in a dose to 900 mg / days. within 2 months was not accompanied by symptoms of overdose. Likely symptoms: bradycardia or tachycardia, decreased blood pressure.
Treatment consists of gastric lavage, patient monitoring and symptomatic therapy.


Aprovel when used with potassium preparations may cause an increase in potassium in the blood. Thiazide diuretics enhance its hypotensive effect.
Drugs containing aliskiren, can not be used in conjunction with Aprovel in diabetes or renal failure, because there is a high risk of a significant reduction in blood pressure, impaired renal function and the occurrence of hyperkalemia.
When used with lithium preparations, control of lithium in the blood is recommended.
NSAIDs weaken the hypotensive effect, increase the level of potassium and the risk of renal dysfunction.
Irbesartan does not affect the pharmacokinetics of digoxin.

Terms of sale

You don't need a prescription to buy Aprovel.

Storage conditions

At a temperature not higher than 30 ° C.
Shelf life - 3 years.


Many patients note the effectiveness and convenience in the use of this drug. According to the hypotensive effect of this drug is not inferior to ACE. The antihypertensive effect lasts for 24 hours, because Aprovel is taken 1 time per day. Patients report a dose-dependent decrease in blood pressure.
“With Aprovel achieved stabilization of pressure after a stroke. I measure pressure 3 times a day "
"This drug began to take after Lisinopril, from which appeared sore throat and coughing"
Side effects are transient in nature and most importantly, there are no undesirable effects, characteristic of ACE (in particular, cough). It is noted that the main disadvantage of this drug is quite high cost.

Write a review

Please login or register to review

Sign Up for Newsletters