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Safocid tabs #12

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Safocid user manualTo buy Safocid just add it to your cartThe drug Safocid is a pharmacological group of combined medicines with antifungal, antibacterial and antiprotozoal therapeutic effect. The drug is used to treat infectious ..

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Safocid user manual

To buy Safocid just add it to your cart

The drug Safocid is a pharmacological group of combined medicines with antifungal, antibacterial and antiprotozoal therapeutic effect. The drug is used to treat infectious pathology caused by agents that are sensitive to the active components of the drug.

Composition and form of release

The drug is available as a set of 3 types of tablets, which are intended for oral administration (oral administration). The first set is presented by Fluconazole tablets. They have a round plane-cylindrical shape and a pink color. The main active substance is fluconazole, its content in one tablet is 150 mg. They also include auxiliary components, which include:
    Calcium hydrogenphosphate.
    Silica.
    Microcrystalline cellulose.
    Croscarmellose sodium.
    Magnesium stearate.
    Colloidal silicon dioxide.
    Crimson dye.
The second set of Azithromycin is presented by tablets having a capsular biconvex form, they are covered with a film membrane of pink color. The main active substance is azithromycin, its content in one tablet is 1048 mg. Also in the composition of this group of tablets are auxiliary substances:
    Croscarmellose sodium.
    Magnesium stearate.
    Sodium lauryl sulfate.
    Colloidal silicon dioxide.
    Povidone K30.
    Talc.
    Titanium dioxide.
    Dye.
The third set of Secnidazole is also presented by tablets that have a capsular shape with a biconvex surface and white color. The main active ingredient is secnidazole, the content of which in one tablet is 1000 mg. The auxiliary substances of this set of tablets are:
    Magnesium stearate.
    Microcrystalline cellulose.
    Carboxymethyl starch of sodium.
    Povidone.
    Talc.
    Corn starch.
    Colloidal silicon dioxide.
    Macrogol.
    Diethyl phthalate.
Safocid tablets are packaged in a contiguous cell pack of 4 pieces, which are represented by the 1st tablet fluconazole, the 1st tablet azithromycin and 2 tablets secnidazole. A cardboard bundle contains 1 or 3 contour squares, as well as instructions for use.

Pharmacodynamics and pharmacokinetics

Pharmacological action of tablets Safocid is determined by the active substances of the kits:
    Fluconazole is an antifungal agent that blocks the synthesis of the ergosterol compound necessary for the normal functional state of the cell wall. Fluconazole has a wide spectrum of activity, it suppresses growth, reproduction, and also leads to the death of various species of fungi (dermatophytes, Candida fungi, mold fungi).
    Azithromycin is an antibiotic of the macrolide group, inhibits the synthesis of protein compounds in a bacterial cell by blocking the S50 subunit by ribosomes. This antibiotic has a wide spectrum of activity against various gram-positive and gram-negative bacteria.
    Secnidazole is an antibacterial agent that is a synthetic derivative of nitroimidazole. It inhibits the growth and multiplication of anaerobic bacteria and protozoan unicellular microorganisms.
After taking Safocid tablets inside it, the active ingredients are quickly and almost completely absorbed into the systemic bloodstream. They are metabolized in the liver with the formation of inactive decay products, which are excreted in urine and bile.

Indications for use

The medical indication for taking Safocid tablets is etiotropic therapy of infectious pathology with predominantly sexual transmission, in which the inflammatory process is caused by several microorganisms simultaneously (combined infection) - gonorrhea, trichomoniasis, mycoplasmosis, ureaplasmosis, chlamydia, and fungal infections (candidiasis of urogenital tract structures) . Such infections are accompanied by the development of the inflammatory process in the urethra (urethritis), the bladder (cystitis), the vagina and vulva (vulvovaginitis), the cervix (cervicitis) in women.


Contraindications for use

In some pathological and physiological processes of the patient's body, the use of Sabocid tablets is contraindicated, including:
    Simultaneous administration of drugs that affect the functional activity of the heart and prolong the QT interval (cisapride, ergotamine, dihydroergotamine, erythromycin, pimozide, quinidine, astemizole).
    Severe insufficiency of the functional activity of the liver or kidneys.
    Organic pathology of central nervous system structures.
    Individual intolerance to any of the components of the drug.
    Pregnancy at any time of the current.
    Lactation period (breastfeeding).
    Age of the patient is less than 18 years.
With caution, the drug is used with a moderate decrease in the functional activity of the liver and kidneys, a violation of the rhythm of contractions of the heart (arrhythmia). Before prescribing the Safocid tablets, the doctor must be sure that there are no contraindications.

Dosing and Administration

Tablets Safocid intended for oral administration. According to medical indications, 4 tablets are taken once (all kits containing 1 tablet of fluconazole, 1 tablet of azithromycin, 2 tablets of sekrididazole) once. If necessary, the doctor can prescribe a second reception of 4 tablets from a contour cell package.

Side effects

Against the background of taking the tablets Safocid possible the development of negative pathological reactions, caused by the active ingredients. Side effects caused by fluconazole include unwanted reactions from various organs and systems:
    Digestive system - bloating (flatulence), nausea, periodic abdominal pain, vomiting, dry mouth, impaired taste, impaired functional activity of the liver.
    Nervous system - headache, periodic dizziness, sleep disturbances (insomnia or drowsiness), trembling of hands (tremor), convulsions.
    Cardiovascular system - a violation of the rhythm of contractions of the heart (arrhythmia).
    The blood system and red bone marrow - a decrease in the number of leukocytes (leukocytopenia), neutrophils (neutropenia), granulocytes (agranulocytosis).
    Skin and its appendages - hair loss (alopecia), increased sweating (hyperhidrosis).
    Musculoskeletal system - pain in the muscles (myalgia), joints (arthralgia).
    Metabolism - a decrease in the level of potassium ions (hypokalemia), increased cholesterol concentrations (hypercholesterolemia) and free fats (hypertriglyceridemia) in the blood.
    Allergic reactions - skin rash, its itching, epidermal necrolysis with death of skin cells, anaphylactic reactions in the form of urticaria, angioedema, quincke, anaphylactic shock.
Azithromycin can also cause the development of negative pathological reactions from various organs and systems:
    Digestive system - nausea, periodic vomiting, constipation, impaired appetite, impaired functional activity of the liver, inflammation of the liver (hepatitis), pancreas (pancreatitis), large intestine (nonspecific colitis), discoloration of the tongue.
    Nervous system - headache, dizziness, convulsions, drowsiness or insomnia, aggressive behavior of the patient, anxiety, nervousness, recurrent syncope.
    Cardiovascular system - the appearance of a palpitation, pain in the heart, palpitations (tachycardia).
    Organs of the senses - hearing impairment up to deafness, which has a reversible character, noise in the ears.
    The blood system and red bone marrow - a decrease in the number of leukocytes (leukocytopenia), lymphocytes (lymphopenia), neutrophils (neutropenia), platelets (thrombocytopenia) in the blood.
    Allergic reactions - rash on the skin, itching, hives, reminiscent of nettle burn, angioedema Quincke with pronounced edema of soft tissues with a predominant localization in the face and external genital organs.
Seknidazole can also cause negative pathological reactions from various organs and systems against the background of the drug:
    The digestive system - nausea, periodic vomiting and abdominal pain, inflammation of the tongue (glossitis), oral mucosa (stomatitis), the appearance of metallic taste in the mouth.
    Nervous system - a violation of coordination of movements, dizziness, peripheral nerves (neuropathy), violation of skin sensitivity (paresthesia).
    The blood system and red bone marrow - a decrease in the number of leukocytes (leukocytopenia) in the blood.
    Allergic reactions - hives, characterized by the appearance of a characteristic rash and swelling, reminiscent of a nettle burn.
The development of any negative pathological reactions against the background of taking Safocid tablets is the basis for discontinuing the use of the drug and referring to a medical specialist.

special instructions

Prior to the appointment of Safocid tablets, the doctor necessarily excludes the presence of contraindications, and also draws attention to a few special instructions, which include:
    It is not recommended to take the drug together with antacids (drugs that reduce the acidity of the stomach). Allowed to take these drugs at intervals of 2 hours.
    Excluded is the use of alcohol against the background of the drug.
    Against the background of taking Safocid tablets, it is possible to obtain a false positive result of the reaction of treponem immobilization, which is carried out for the diagnosis of syphilis.
    The active components of all sets of Safocid tablets can interact with drugs from other pharmacological groups. In case of their application, the attending physician should be warned about this.
    The drug has no direct effect on the functional state of the cerebral cortex. In connection with the possible development of side effects from the central nervous system on the background of taking the drug is recommended to abandon the work associated with increased concentration of attention and sufficient speed of psychomotor reactions.
In the pharmacy network, Safocid tablets are dispensed only on prescription. The use of the drug alone without proper prescription by a medical specialist is excluded.

Overdose

To date, cases of overdose with Safocid tablets have not been recorded. If the therapeutic dose is significantly exceeded, the symptoms of side effects may appear or increase. In particular, hallucinations, paranoid behavior, temporary hearing loss, nausea, vomiting, and diarrhea can develop. Treatment of an overdose is symptomatic, since there is no specific antidote.

Terms and conditions of storage

The shelf life of the Safocid tablets is 3 years from the date of their manufacture. The drug should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of not more than 30 ° C.

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